周英
生物学专业：博士生导师
食品科学与工程专业：硕士生导师
生物化工专业：硕士生导师
生物与医药专业（生物工程领域）：硕士生导师
周英，博士，副教授。2008年毕业于公司，获生物化工博士学位，留校任教至今，兼任上海市食品学会副秘书长。2018年-2019年赴荷兰瓦赫宁根大学微生物研究所进行访学。代表性成果发表在Cell Host & Microbe, PNAS, Biosensors and Bioelectronics, ACS Synthetic Biology等期刊上。主持和参与了多项国家自然科学基金、国家重点研发计划、上海市科委重点项目、中央高校基本科研业务费探索基金等。
研究方向：
1. 构建工程化益生菌用于肠道疾病的诊疗。
利用益生菌为底盘细胞，解析细胞与环境中的信息和物质传递机制，设计构建胞内传感、记录、调控等不同代谢功能模块，赋予工程化益生菌智能感应及原位诊疗功能，实现全细胞在肠道疾病及慢性代谢疾病中及时、高效的诊断和治疗的目标。
2. 解析致病菌在肠道疾病中作用机制。
翻译后修饰角度解析沙门氏菌、大肠杆菌等肠道致病菌在侵染宿主、增殖过程中的调控机制，开展宿主环境中小分子信号物质激活调控蛋白，引起关键位点的酰基化修饰从而导致侵染能力，期望达到控制、预防食源性疾病对宿主的侵害，维护肠道健康。
教学：
本科：《食品微生物学》、《食品工艺学》、《食品感官分析》
硕士：《现代微生物学》
近三年代表性论文（*通讯作者）：
(1) Zhen-Ping Zou, Yue Du, Ting-Ting Fang, Ying Zhou*, Bang-Ce Ye*. Biomarker-responsive engineered probiotic diagnoses, records, and ameliorates inflammatory bowel disease in mice, Cell Host & Microbe. 2023, 31(2): 199-212.
(2) Zhen-Ping Zou, Yu-Hang Fan, Yue Du, Ting-Ting Fang, Wei Du, Ying Zhou*, Bang-Ce Ye*. Protocol for engineering E. coli Nissle 1917 to diagnose, record, and ameliorate inflammatory bowel disease in mice. STAR Protocols. 2023. (Accepted)
(3) Shu-Shan Cai, Liu-Qing Zhang, Qian Zhang, Bang-Ce Ye, Ying Zhou*. Acetylation of NarL K188 and K192 is Involved in Regulating Escherichia coli Anaerobic Nitrate Respiration. Applied Microbiology and Biotechnology. 2022. Nov; 106(21):7209-7221
(4) Li Zhao#, Di You#, Bin-Cheng Yin*, Ying Zhou*, Bang-Ce Ye*. Acylation driven by intracellular metabolites in host cells inhibits Cas9 activity used for genome editing. PNAS Nexus. 2022. 1:1-8
(5) Jin-Yu Wang, Ying Zhou, Bin-Cheng Yin*, Bang-Ce Ye*. An miRISC-initiated DNA Nanomachine for Monitoring MicroRNA Activity in Living Cells. Biosensors and Bioelectronics. 2022. 220: 114828
(6) Bai-Qing Zhang, Zong-Qin Chen, Yu-Qi Dong, Di You*, Ying Zhou*, Bang-Ce Ye*. Selective recruitment of stress-responsive mRNAs to ribosomes for translation by acetylated protein S1 during nutrient stress in Escherichia coli. Communications Biology. 2022. 5:892
(7) Tian-Tian Chang, Zhi-Wei Lin, Bang-Ce Ye, Wei-Bing Liu*, Ying Zhou*. Efficient biodegradation of Di-(2-ethylhexyl) Phthalate by a novel strain Nocardia asteroides LMB-7 isolated from electronic waste soil. Scientific Reports. 2022.12:15262
(8) Zhen-Ping Zou, Ying Yang, Junshan Wang, Ying Zhou*, Bang-Ce Ye*. Coupling split-lux cassette with a toggle switch in bacteria for ultrasensitive blood markers detection in feces and urine. Biosensors and Bioelectronics. 2022. 214:114520-114528.
(9) Ting-Ting Fang, Zhen-Ping Zou, Ying Zhou*, Bang-Ce Ye*. Prebiotics-Controlled Disposable Engineered Bacteria for Intestinal Diseases. ACS Synthetic Biology. 2022. 11(9):3010-3014.
(10) Yan Zhang, Zhen-Ping Zou, Sheng-Yan Chen, Wen-Ping Wei, Ying Zhou, Bang-Ce Ye*. Design and optimization of E. coli artificial genetic circuits for detection of explosive composition 2,4-dinitrotoluene. Biosensors and Bioelectronics. 2022. 207: 114205.
(11) Yi-Lin Shen, Liu-Qing Zhang, Ying Yang, Bin-Cheng Yin, Bang-Ce Ye, Ying Zhou*. Advances in role and mechanism of lactic acid bacteria in treating obesity. Food Bioengineering, 2022, 1: 1-10.
(12) 张萍, 魏文平, 周英, 叶邦策. 解脂耶氏酵母中光控表达系统的构建及其应用研究. 合成生物学. 2021, 2(5):778-791.
(13) Shu-Shan Cai, Ying Zhou*, Bang-Ce Ye*. Reducing reproductive toxicity activity of Lactiplantibacillus plantarum: A review of mechanisms and prospect. Environ Sci Pollut Res. 2021. 28(28): 36927-36941.
(14) Wei-Bing Liu, Zhi-Wei Lin, Ying Zhou*, Bang-Ce Ye*. Overexpression of Capsular Polysaccharide Biosynthesis Protein in Lactobacillus plantarum P1 to enhance Capsular Polysaccharide production of di-n-butyl phthalate adsorption. J. Microbiol. Biotechnol. 2021. 31(11): 1545-1551.
(15) Yu-Hang Fan, Yi-Lin Shen, Zhi-Wei Lin, Ying Zhou*, Bang-Ce Ye*. Key role of exopolysaccharide on di-butyl phthalate adsorbing by Lactobacillus plantarum CGMCC18980. Appl. Microbiol. Biotechnol. 2021. 105, 2587-2595.
(16) Xue Shi, Changhui Hu, Shushan Cai, Xinyi Tao, Ying Zhou*, Hauke Smidt, Bangce Ye*. Protective Effects of Lactobacillus plantarum P1 against Toxicity of the Environmental Estrogen Di-n-butyl Phthalate in Rats. Beneficial Microbes. 2020. 11(8):803-813.
(17) Wenping Wei, Ping Zhang, Yanzhe Shang, Ying Zhou, Bang-Ce Ye. Metabolically engineering of Yarrowia lipolytica for the biosynthesis of naringenin from a mixture of glucose and xylose. Bioresource Technology. 2020. 314:123726
联系方式：
上海市梅陇路130号公司 pg官方电子平台，200237
办公室：实验十八楼713室
电话：021-64253832
E-mail: zhouying@ecust.edu.cn